IHC of TCL1 on an FFPE Lymphoma Tissue
| Intended Use | For In Vitro Diagnostic Use | |||||||||||||||||||||||||||||||||||
| Summary and Explanation | T-cell leukemia/lymphoma protein 1 (TCL1, TCL1A, p14TCL1) is involved in T-cell prolymphocytic leukemia (T-PLL) and is normally found in the nucleus and cytoplasm of lymphoid lineage cells during early embryogenesis. Chromosomal translocations may lead to overexpression of TCL1, resulting in T-cell leukemia and B-cell lymphoma. TCL1 is expressed in more differentiated B-cells, under both reactive and neoplastic conditions, from antigen committed B-cells and in germinal center B-cells. TCL1 is down-regulated in the latest stage of B-cell differentiation. TCL1 is overexpressed in Burkitt Lymphoma, the majority of AIDS-related non-Hodgkin’s Lymphoma-designated Immunoblastic Plasmacytoid Lymphoma, Lymphoblastic Lymphoma, Chronic Lymphocytic Leukemia, Mantle Cell Lymphoma, Follicular Lymphoma, Diffuse Large B-cell Lymphoma, and Primary Cutaneous B-cell Lymphoma. Therefore, the most useful application of anti- TCL1 is the discrimination of B-cell lymphomas from T-cell lymphomas, CD30+ Anaplastic Large Cell Lymphomas, Multiple Myeloma, and Marginal Zone B-cell Lymphoma. | |||||||||||||||||||||||||||||||||||
| Antibody Type | Rabbit Monoclonal | Clone | EP105 | |||||||||||||||||||||||||||||||||
| Isotype | IgG | Reactivity | Paraffin, Frozen | |||||||||||||||||||||||||||||||||
| Localization | Nuclear, Cytoplasmic | Control | Tonsil, Lymph Node | |||||||||||||||||||||||||||||||||
| Presentation | TCL1 is a rabbit monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative. | |||||||||||||||||||||||||||||||||||
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| Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product. | ||||||||||||||||||||||||||||||||||||
