IHC of S-100 on an FFPE Malignant Melanoma Tissue
| Intended Use | For In Vitro Diagnostic Use | |||||||||||||||||||||||||||||||||||
| Summary and Explanation | S-100 protein is a type of low-molecular weight protein found in vertebrates, characterized by two calcium-binding sites of the helix-loop-helix conformation. S-100 is normally present in cells derived from the neural crest (Schwann cells, melanocytes and glial cells), chondrocytes, adipocytes, myoepithelial cells, macrophages, Langerhans cells, dendritic cells, and keratinocytes. It may be present in some breast epithelial cells. Several members of the S-100 protein family are useful as markers for certain tumors and epidermal differentiation. The S-100 protein can be found in melanomas, 50% of Malignant Peripheral Nerve Sheath Tumors, and Clear Cell Sarcomas.Almost all Malignant Melanomas and cases of Histiocytosis X are positive for S-100 protein. Despite the fact that S-100 protein is a ubiquitous substance, its demonstration is of great value in the identification of several neoplasms, particularly Melanomas. | |||||||||||||||||||||||||||||||||||
| Antibody Type | Mouse Monoclonal | Clone | 4C4.9 | |||||||||||||||||||||||||||||||||
| Isotype | IgG2a | Reactivity | Paraffin, Frozen | |||||||||||||||||||||||||||||||||
| Localization | Cytoplasmic | Control | Melanoma | |||||||||||||||||||||||||||||||||
| Presentation | S-100 is a mouse monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative. | |||||||||||||||||||||||||||||||||||
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| Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product. | ||||||||||||||||||||||||||||||||||||
