IHC of p27 on an FFPE Breast Adenocarcinoma Tissue
| Intended Use | For In Vitro Diagnostic Use | |||||||||||||||||||||||||||||||||||
| Summary and Explanation | p27KIP1 is a cell cycle regulatory mitotic inhibitor of Cdk activity. p27KIP1 is a candidate-tumor suppressor gene, and has been proposed to function as a possible mediator of TGF beta induced G1 arrest. p27 is up-regulated in response to antimitogenic stimuli. The increased protein expression of p27 results in cellular arrest by binding to cyclin/Cdk complexes such as cyclin D1/Cdk4. Low p27 expression has been associated with unfavorable prognosis in Renal-cell Carcinoma,Colon Carcinoma, Small Breast Carcinomas, Non-small-cell Lung Carcinoma, Hepatocellular Carcinoma, Multiple Myeloma, lymph node metastases in Papillary Carcinoma of the Thyroid, and a more aggressive phenotype of Carcinoma in the Cervix. | |||||||||||||||||||||||||||||||||||
| Antibody Type | Mouse Monoclonal | Clone | SX53G8 | |||||||||||||||||||||||||||||||||
| Isotype | IgG1/K | Reactivity | Paraffin, Frozen | |||||||||||||||||||||||||||||||||
| Localization | Nuclear | Control | Prostate, Colon Adenocarcinoma, Non-Small Cell Lung Carcinoma | |||||||||||||||||||||||||||||||||
| Presentation | Anti-p27 is a mouse monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative. | |||||||||||||||||||||||||||||||||||
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| Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product. | ||||||||||||||||||||||||||||||||||||
