IHC of Myosin Smooth Muscle Heavy Chain on an FFPE Appendix Tissue
| Intended Use | For In Vitro Diagnostic Use | |||||||||||||||||||||||||||||||||||
| Summary and Explanation | Myosins are a large family of motor proteins found in eukaryotic tissues. They are responsible for actin-based motility. Smooth Muscle Myosin, Heavy Chain is a cytoplasmic structural protein that is a major component of the contractile apparatus of the smooth muscle cells, as well as a myoepithelium-associated protein. SMM-H24 is a mouse monoclonal antibody to Smooth Muscle Myosin, Heavy Chain that reacts with human visceral and vascular smooth muscle cells. The antibody also reacts with human myoepithelial cells. It is very helpful in distinguishing between benign sclerosing breast lesions and infiltrating Carcinomas in difficult cases, since it strongly stains the myoepithelial layer in the benign lesions while it is negative in the infiltrating Carcinomas. | |||||||||||||||||||||||||||||||||||
| Antibody Type | Mouse Monoclonal | Clone | BSB-17 | |||||||||||||||||||||||||||||||||
| Isotype | IgG1/K | Reactivity | Paraffin, Frozen | |||||||||||||||||||||||||||||||||
| Localization | Cytoplasmic | Control | Intestine, Breast, Appendix | |||||||||||||||||||||||||||||||||
| Presentation | Smooth Muscle Myosin, Heavy Chain is a mouse monoclonal antibody derived from cell culture supernatantthat is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azideas a preservative. | |||||||||||||||||||||||||||||||||||
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| Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product. | ||||||||||||||||||||||||||||||||||||
