IHC of Myogenin on an FFPE Rhabdomyosarcoma Tissue
| Intended Use | For In Vitro Diagnostic Use | |||||||||||||||||||||||||||||||||||
| Summary and Explanation | Myogenin is a transcription factor active in muscles. In particular, it is a myogenic regulatory factor. Myogenin is a member of a family of myogenic regulatory genes, which includes MyoD, myf5 and MRF4. These genes encode a set of transcription factors which are essential for muscle development. Expression of myogenin is restricted to cells of skeletal-muscle origin. It is, therefore, a useful marker for tumors of the muscle lineage, being strongly expressed in Alveolar Rhabdomyosarcomas. Anti-myogenin labels the nuclei of myoblasts in developing muscle tissue, and is expressed in tumor cell nuclei of Rhabdomyosarcoma and some Leiomyosarcomas. Positive nuclear staining may occur in Wilm’s Tumor. | |||||||||||||||||||||||||||||||||||
| Antibody Type | Mouse Monoclonal | Clone | F5D | |||||||||||||||||||||||||||||||||
| Isotype | IgG1/K | Reactivity | Paraffin, Frozen | |||||||||||||||||||||||||||||||||
| Localization | Nuclear | Control | Rhabdomyosarcoma | |||||||||||||||||||||||||||||||||
| Presentation | Myogenin is a mouse monoclonal antibody derived from cell culture supernatant that is concentrated,dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative. | |||||||||||||||||||||||||||||||||||
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| Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product. | ||||||||||||||||||||||||||||||||||||
