IHC of Myelin Basic Protein on an FFPE Brain Tissue
| Intended Use | For In Vitro Diagnostic Use | |||||||||||||||||||||||||||||||||||
| Summary and Explanation | Myelin Basic Protein (MBP) is a protein believed to be important in the process of myelination of nerves in the central nervous system (CNS). The pool of MBP in the central nervous system is very diverse, with several splice variants being expressed and a large number of post-translational modifications on the protein, which include phosphorylation, methylation, deamidation and citrullination.MBP has been demonstrated in Neuromas, Neurofibromas, and Neurogenic Sarcomas. However, other spindle-cell neoplasms do not stain with this antibody. Immunoreactivity for MBP in Granular-cell Tumors strengthens the concept of a Schwann-cell derivation of these lesions. Unlike other nervous system proteins such as GFAP and S-100, MBP has not been demonstrated in melanocytes or tumors derived from them. | |||||||||||||||||||||||||||||||||||
| Antibody Type | Rabbit Polyclonal | Clone | N/A | |||||||||||||||||||||||||||||||||
| Isotype | IgG | Reactivity | Paraffin, Frozen | |||||||||||||||||||||||||||||||||
| Localization | Cytoplasmic | Control | Brain, Neuroblastoma | |||||||||||||||||||||||||||||||||
| Presentation | Myelin Basic Protein is a purified immunoglobulin fraction of rabbit antiserum that is filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative. | |||||||||||||||||||||||||||||||||||
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| Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product. | ||||||||||||||||||||||||||||||||||||
