IHC of Ksp-Cadherin on an FFPE Kidney Tissue
| Intended Use | For In Vitro Diagnostic Use | |||||||||||||||||||||||||||||||||||
| Summary and Explanation | Ksp-Cadherin (Kidney-specific Cadherin) is a novel, kidney-specific member of the Cadherin family of cell-adhesion molecules. Within the kidney, Ksp-Cadherin is found exclusively in the basolateral membrane of renal tubular epithelial cells and collecting duct cells, and not in glomeruli, renal interstitial cells, or blood vessels. Different Cadherins, including E-Cadherin, Cadherin-6, and N-Cadherin, have been investigated in Renal Cell Cancers, demonstrating possible correlations of tumor differentiation and the presence of lymph node metastasis with loss of Cadherins. Ksp-Cadherin has been used to distinguish Chromophobe Renal-Cell Carcinoma from Oncocytoma. Studies have found a membranous pattern of staining in 96% of 30 Chromophobe Carcinomas, and in only 6% of 31 Oncocytomas, leading to conclude that this is a useful antibody in differentiating these two lesions. On the other hand, another study found Ksp-Cadherin positivity in 100% of 13 chromophobe RCCs, and 95% of 20 Oncocytomas. | |||||||||||||||||||||||||||||||||||
| Antibody Type | Mouse Monoclonal | Clone | 4H6/F9 | |||||||||||||||||||||||||||||||||
| Isotype | IgG1 | Reactivity | Paraffin, Frozen | |||||||||||||||||||||||||||||||||
| Localization | Membranous, Cytoplasmic | Control | Thyroid, Kidney, Chromophobe Renal Cell Carcinoma | |||||||||||||||||||||||||||||||||
| Presentation | Ksp-Cadherin is a mouse monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative. | |||||||||||||||||||||||||||||||||||
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| Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product. | ||||||||||||||||||||||||||||||||||||
