IHC of Helicobacter pylori on an FFPE Stomach Tissue
| Intended Use | Analyte Specific Reagent | |||||||||||||||||||||||||||||||||||
| Summary and Explanation | Helicobacter pylori is a Gram-negative, microaerophilic bacterium found in the stomach, and may be present in other parts of the body, such as the eye. H. pylori is a helix-shaped Gram-negative bacterium about 3 μm long with a diameter of about 0.5 μm. It is microaerophilic; that is, it requires oxygen, but at lower concentration than is found in the atmosphere.H. pylori could be present in patients with chronic gastritis and gastric ulcers and is also linked to the development of duodenal ulcers and stomach cancer. However, over 80% of individuals infected with the bacterium are asymptomatic and it may play an important role in the natural stomach ecology. The strain of H. pylori to which a person is exposed may influence the risk of developing gastric cancer. Strains of H. pylori that produce high levels of two proteins, vacuolating toxin A (VacA) and the cytotoxin-associated gene A (CagA), appear to cause greater tissue damage than those that produce lower levels or that lack those genes completely. These proteins are directly toxic to cells lining the stomach and signal strongly to the immune system that an invasion is underway.This antibody reacts with Helicobacter pylori on the surface of epithelial cells of infected specimens. | |||||||||||||||||||||||||||||||||||
| Antibody Type | Mouse Monoclonal | Clone | BSB-37 | |||||||||||||||||||||||||||||||||
| Isotype | IgG1/K | Reactivity | Paraffin, Frozen | |||||||||||||||||||||||||||||||||
| Localization | Cell Wall | Control | H.Pylori Infected Stomach Mucosa | |||||||||||||||||||||||||||||||||
| Presentation | H pylori is a monoclonal antibody derived from cell culture supernatant that isconcentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative. | |||||||||||||||||||||||||||||||||||
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| Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product. | ||||||||||||||||||||||||||||||||||||
