IHC of GFAP on an FFPE Brain Tissue
| Intended Use | For In Vitro Diagnostic Use | |||||||||||||||||||||||||||||||||||
| Summary and Explanation | Glial fibrillary acidic protein or GFAP is a Type III protein of the intermediate filaments principally found in astrocytes in the central nervous system, but can also be found in neurons, hepatic stellate cells, kidney mesangial cells, pancreatic stellatecells, and Leydig cells. It has a role in the cytoskeleton of the astrocyte and possibly many other stellate-shaped cells. Antibodies to GFAP are very useful as markers of astrocytic cells. In addition, many types of brain tumors, presumably derived from astrocytic cells, heavily express GFAP. This marker is mainly used to distinguish neoplasms of astrocytic origin from other neoplasms in the central nervous system. | |||||||||||||||||||||||||||||||||||
| Antibody Type | Mouse Monoclonal | Clone | G-A-5 | |||||||||||||||||||||||||||||||||
| Isotype | IgG1 | Reactivity | Paraffin, Frozen | |||||||||||||||||||||||||||||||||
| Localization | Cytoplasmic | Control | Brain | |||||||||||||||||||||||||||||||||
| Presentation | GFAP is a mouse monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative. | |||||||||||||||||||||||||||||||||||
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| Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product. | ||||||||||||||||||||||||||||||||||||
