IHC of E2F4 on an FFPE Prostatic Adenocarcinoma Tissue
| Intended Use | For In Vitro Diagnostic Use | |||||||||||||||||||||||||||||||||||
| Summary and Explanation | E2F4 is a transcritption factor protein that is encoded by the E2F4 gene on Chromosome 16.E2F4 is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. This protein binds to all three of the tumor suppressor proteins pRB, p107 and p130. In quiescent cells, E2F4 is primarily localized in the nucleus but translocate to cytoplasm when the retinoblastoma family members are phosphorylated in response to mitogen.E2F4 is constitutively expressed throughout the cell. Squamous cell carcinomas of the salivary gland intense E2F4 staining, while most of the pleomorphic adenoma cells show nuclear reactivity of E2F4. Reduced expression of E2F4 has been reported in sporadic Burkitt lymphoma (sBL), and may play a role in Burkitt lymphoma tumorigenesis. | |||||||||||||||||||||||||||||||||||
| Antibody Type | Rabbit Monoclonal | Clone | EP252 | |||||||||||||||||||||||||||||||||
| Isotype | IgG | Reactivity | Paraffin, Frozen | |||||||||||||||||||||||||||||||||
| Localization | Nuclear | Control | Tonsil, Placenta, Testis, Breast, Cervix, Colon, Cervical Cancer, Prostate Carcinoma | |||||||||||||||||||||||||||||||||
| Presentation | E2F4 is a rabbit monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative. | |||||||||||||||||||||||||||||||||||
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| Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product. | ||||||||||||||||||||||||||||||||||||
