IHC of CK 17 on an FFPE Cervical Cancer Tissue
| Intended Use | For In Vitro Diagnostic Use | |||||||||||||||||||||||||||||||||||
| Summary and Explanation | Cytokeratin 17 is a Type I cytokeratin with a MW of 46 kD found sometimes in association with Cytokeratin 7. It is found in nail beds, hair follicles, sebaceous glands, and other epidermal appendages. Mutations in the gene encoding this protein lead to Jackson-Lawler type Pachyonychia Congenita and Steatocystoma Multiplex. Cytokeratin 17 antibody has been used to distinguish immature Cervical Squamous Metaplasia from high grade Cervical Intraepithelial Neoplasia (CIN III). Anti-CK 17 also labels myoepithelial cells in the benign breast tissue. CK 17 labeling of Breast Carcinoma cells (so-called basal phenotype) has been associated with a poor prognosis. | |||||||||||||||||||||||||||||||||||
| Antibody Type | Rabbit Monoclonal | Clone | EP98 | |||||||||||||||||||||||||||||||||
| Isotype | IgG | Reactivity | Paraffin, Frozen | |||||||||||||||||||||||||||||||||
| Localization | Cytoplasmic | Control | Skin, Testis, Breast, Cervix, Colon, Salivary Gland, Cervical Carcinoma, Bladder TCC, Transitional Cell Carcinoma | |||||||||||||||||||||||||||||||||
| Presentation | Cytokeratin 17 is a rabbit monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative. | |||||||||||||||||||||||||||||||||||
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| Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product. | ||||||||||||||||||||||||||||||||||||
| * The Cytokeratin 17 antibody, clone EP98, has been manufactured using Epitomics RabMab® technology covered under Patent No.’s 5,675,063 and 7,402,409. | ||||||||||||||||||||||||||||||||||||
