IHC of Claudin-1 on an FFPE Skin Tissue
| Intended Use | For In Vitro Diagnostic Use | |||||||||||||||||||||||||||||||||||
| Summary and Explanation | Claudin 1 is an integral membrane protein and a component of tight junction strands. Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are composed of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. Claudin-1 stains membraines of cells and is found in nearly all carcinomas, with stains much stronger in carcinoma cells than in normal tissue cells. | |||||||||||||||||||||||||||||||||||
| Antibody Type | Rabbit Polyclonal | Clone | Polyclonal | |||||||||||||||||||||||||||||||||
| Isotype | IgG | Reactivity | Paraffin, Frozen | |||||||||||||||||||||||||||||||||
| Localization | Membranous, Cytoplasmic | Control | Skin, Small intestine. Perineurioma, Neurofibroma, colon Carcinoma | |||||||||||||||||||||||||||||||||
| Presentation | Claudin 1 is a Rabbit Polyclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative. | |||||||||||||||||||||||||||||||||||
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| Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product. | ||||||||||||||||||||||||||||||||||||
