IHC of CD71 on an FFPE Bone Marrow Tissue
| Intended Use | For In Vitro Diagnostic Use | |||||||||||||||||||||||||||||||||||
| Summary and Explanation | CD71, also known as Transferrin Receptor Protein 1 (TfR1) is a protein encoded by the TFRC gene. CD71 is required for iron delivery from transferrin to cells. It is most highly expressed on placental syncytiotrophoblasts, myocytes, basal keratinocytes, hepatocytes, endocrine pancreas, spermatocytes, and erythroid precursors. The level of transferrin receptor expression is highest in the early erythroid precursors through intermediate normoblast phase, after which expression decreasess through the reticulocyte phase. The high level of CD71 within erythroid precursors makes it an excellent marker for erythroid components within bone marrow biopsy specimens without interference from mature erythrocytes. It may also be used in the determination of erythroid leukemia, benign erythroid proliferative disorders, and myelodysplastic syndrome. | |||||||||||||||||||||||||||||||||||
| Antibody Type | Mouse Monoclonal | Clone | 10F11 | |||||||||||||||||||||||||||||||||
| Isotype | IgGb2 | Reactivity | Paraffin, Frozen | |||||||||||||||||||||||||||||||||
| Localization | Cytoplasmic, Membranous | Control | Kidney, Bone Marrow, Placenta | |||||||||||||||||||||||||||||||||
| Presentation | CD71 is a mouse monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative. | |||||||||||||||||||||||||||||||||||
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| Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product. | ||||||||||||||||||||||||||||||||||||
