IHC of CD57 on an FFPE Tonsil Tissue
| Intended Use | For In Vitro Diagnostic Use | |||||||||||||||||||||||||||||||||||
| Summary and Explanation | CD57 (NK-1) recognizes an oligosaccharide (MW 100-110 kDa) antigenic determinant on myeloid cells and on a variety of polypeptides, lipids and chondroitan sulfate proteoglycans. This surface antigen is associated with myelin-associated glycoprotein (MAG). The CD57 antigen is present on 15-20% of normal peripheral blood mononuclear cells. It is expressed on a subset of natural killer cells (60%) and on a subset of T-lymphocytes. This carbohydrate is also present on N-CAM in the nervous system. Follicular Center-cell Lymphomas often contain many NK cells within the neoplastic follicles. NK-1 reportedly also reacts with a variety of cell types in non-lymphoid tissues. NK-1 stains neuroendocrine cells and their tumors, including Carcinoid Tumor and Medulloblastomas. NK-1 also reacts with a variety of cell types in non-lymphoid tissues, including Neurofibroma, Ganglioneuroma, and Prostate Carcinoma. | |||||||||||||||||||||||||||||||||||
| Antibody Type | Mouse Monoclonal | Clone | BSB-10 (CD57/B8) | |||||||||||||||||||||||||||||||||
| Isotype | IgM/K | Reactivity | Paraffin, Frozen | |||||||||||||||||||||||||||||||||
| Localization | Membranous | Control | Tonsil, Lymph Node | |||||||||||||||||||||||||||||||||
| Presentation | CD57 is a mouse monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative. | |||||||||||||||||||||||||||||||||||
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| Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product. | ||||||||||||||||||||||||||||||||||||
