IHC of CD45R on an FFPE Tonsil Tissue
| Intended Use | For In Vitro Diagnostic Use | |||||||||||||||||||||||||||||||||||
| Summary and Explanation | CD45R contains an extracellular domain, a single transmembrane segment and two tandem intracyto-plasmic catalytic domains. It is specifically expressed in hematopoietic cells and has been shown to be an essential regulator of T and B-cell antigen-receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen-receptor signaling. CD45R also suppresses JAK kinases, and thus functions as a regulator of cytokine-receptor signaling. CD45R represents a restricted form of the CD45 family, which primarily recognizes only cells of B lineage from proB-cell through mature B lymphocytes and, prior to the availability of anti-CD19 MAbs, was commonly used as a pan B-cell marker. It also reacts with certain activated T-cells, as well as non-MHC restricted lytically active lymphokine-activated killer (LAK) cells. MB1 antibody stains preferentially B-cells and their neoplasms but is less specific, as it will also react with some T-cell Lymphomas and Non-lymphoid Tumors. The antigen for this antibody is in the membrane of all B-cells with the exception of plasma cells and some mature T-cells. | |||||||||||||||||||||||||||||||||||
| Antibody Type | Mouse Monoclonal | Clone | MB1 | |||||||||||||||||||||||||||||||||
| Isotype | IgG1 | Reactivity | Paraffin, Frozen | |||||||||||||||||||||||||||||||||
| Localization | Membranous | Control | Tonsil, Lymph Node | |||||||||||||||||||||||||||||||||
| Presentation | CD45R is a mouse monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative. | |||||||||||||||||||||||||||||||||||
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| Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product. | ||||||||||||||||||||||||||||||||||||
