IHC of CD31 on an FFPE Tonsol Tissue
| Intended Use | For In Vitro Diagnostic Use | |||||||||||||||||||||||||||||||||||
| Summary and Explanation | CD31 is also called PECAM-1 for platelet endothelial cell-adhesion molecule. It plays a key role in removing aged neutrophils from the body. CD-31 is normally found on stem cells, endothelial cells, platelets, macrophages and Kupffer cells, granulocytes, T/NK cells, lymphocytes, megakaryocytes, fibroblasts, osteoclasts and neutrophils. CD-31 is also expressed in certain tumors, including Epithelioid Hemangioendothelioma, Epithelioid Sarcoma-like Hemangioendothelioma, other vascular tumors, Histiocytic malignancies, and Plasmacytomas. It is rarely found in some sarcomas and carcinomas. CD-31 and macrophages play a key role in tissue regeneration. CD31 is widely used to identify the vascular origin of neoplasms, as it is a highly specific and sensitive marker for vascular endothelial cells. | |||||||||||||||||||||||||||||||||||
| Antibody Type | Mouse Monoclonal | Clone | 1A10 | |||||||||||||||||||||||||||||||||
| Isotype | IgG1/K | Reactivity | Paraffin, Frozen | |||||||||||||||||||||||||||||||||
| Localization | Cytoplasmic, Membranous | Control | Tonsil, Placenta, Appendix, Spleen, Kidney | |||||||||||||||||||||||||||||||||
| Presentation | CD31 is a mouse monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative. | |||||||||||||||||||||||||||||||||||
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| Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product. | ||||||||||||||||||||||||||||||||||||
