IHC of CD15 on an FFPE Hodgkin’s Lymphoma Tissue
| Intended Use | For In Vitro Diagnostic Use | |||||||||||||||||||||||||||||||||||
| Summary and Explanation | CD15 is a phosphatidylinositol-anchored transmembrane protein found on neutrophils and which may be involved in phagocytosis. It is expressed in patients with Hodgkin’s Disease, some B-cell Chronic Lymphocytic Leukemias, Acute Lymphoblastic Leukemias, and most Acute Non-Lymphocytic Leukemias. It is also called Lewis x. A positive reaction for CD15 combined with a negative reaction for CD45 and other B and T-lineage markers provides support for Reed-Sternberg cells found in Hodgkin’s disease. Also, this antibody does not detect Mesotheliomas, making it a more frequently used antibody to distinguish Epithelial Mesothelioma from Adenocarcinoma. | |||||||||||||||||||||||||||||||||||
| Antibody Type | Mouse Monoclonal | Clone | MMA | |||||||||||||||||||||||||||||||||
| Isotype | IgM | Reactivity | Paraffin, Frozen | |||||||||||||||||||||||||||||||||
| Localization | Cytoplasmic, Membranous | Control | Tonsil, Lymph Node, Hodgkin’s Lymphoma | |||||||||||||||||||||||||||||||||
| Presentation | CD15 is a mouse monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative. | |||||||||||||||||||||||||||||||||||
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| Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product. | ||||||||||||||||||||||||||||||||||||
