IHC of CD138 on an FFPE Tonsil Tissue
| Intended Use | For In Vitro Diagnostic Use | |||||||||||||||||||||||||||||||||||
| Summary and Explanation | CD138/Syndecan-1 is a transmembrane heparin-sulphate proteoglycan which is made up of one core protein and five glycosaminoglycans. CD138 is expected to play a role in cell adhesion. It is expressed on the surface of pre B-cells and plasma cells but is absent from mature B-cells. Anti-CD138/syndecan-1 is a useful marker for labeling normal and neoplastic plasma cells and Plasmacytoid Lymphomas. It is a selective marker for B-cell Lymphoblastic Leukemia and Lymphoplasmocytoid Leukemia. It is lost from the apoptotic myeloma cells, and thus, is a useful marker for viable Myeloma cells. Various forms of Hodgkin’s Disease have also shown positive staining with this antibody. | |||||||||||||||||||||||||||||||||||
| Antibody Type | Mouse Monoclonal | Clone | B-A38 | |||||||||||||||||||||||||||||||||
| Isotype | IgG1 | Reactivity | Paraffin, Frozen | |||||||||||||||||||||||||||||||||
| Localization | Membranous | Control | Tonsil, Liver, Kidney, Breast, Lymph Node, Cervix, Plasmacytoma | |||||||||||||||||||||||||||||||||
| Presentation | CD138 is a mouse monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative. | |||||||||||||||||||||||||||||||||||
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| Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product. | ||||||||||||||||||||||||||||||||||||
