IHC of CD11c on an FFPE Spleen Tissue
| Intended Use | For In Vitro Diagnostic Use | |||||||||||||||||||||||||||||||||||
| Summary and Explanation | CD11c (1TGAX) is a member of the leukointegrin family and shares the same beta subunit with other members of the leukocyte adhesion molecule family, which include CD11a (LFA-1), CD11b (MAC-1), and CD11d (ITGAD), but has a unique alpha chain. CD11c is a type I transmembrane protien found at high levels on most human dendritic cells, but also on monocytes, macrophages, neutrophils, and some B cells that induces cellular activation and helps trigger neutrophil respiratory burst. CD11c is expressed in Hairy Cell leukemias, Acute Nonlymphocytic Leukemias, and some B-cell Chronic Lymphocytic Leukemias. | |||||||||||||||||||||||||||||||||||
| Antibody Type | Rabbit Monoclonal | Clone | EP157 | |||||||||||||||||||||||||||||||||
| Isotype | IgG | Reactivity | Paraffin, Frozen | |||||||||||||||||||||||||||||||||
| Localization | Cytoplasmic | Control | Bone Marrow, Spleen, Tonsil, Colon, Hairy Cell Leukemia | |||||||||||||||||||||||||||||||||
| Presentation | Cd11c is a rabbit monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative. | |||||||||||||||||||||||||||||||||||
| Availability |
| |||||||||||||||||||||||||||||||||||
| Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product. | ||||||||||||||||||||||||||||||||||||
