| Intended Use | For In Vitro Diagnostic Use |
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| Summary and Explanation | Adrenocorticotropic Hormone (ACTH or corticotropin) is a polypeptide hormone synthesized from POMC, (Pro-opiomelanocortin) and secreted from corticotropes in the anterior lobe of the pituitary gland in response to Corticotropin-releasing Hormone (CRH) released by the hypothalamus. It consists of 39 amino acids. ACTH is a useful marker in the classification of pituitary tumors and the study of pituitary disease. It reacts with ACTH-producing cells (corticotrophs), as well as other tumors (e.g.,some Small-Cell Carcinomas present in lung tissue) causing Paraneoplastic Syndromes by secreting ACTH. |
| Antibody Type | Mouse Monoclonal | Clone | BSB-25 |
| Isotype | IgG1/K | Reactivity | Paraffin, Frozen |
| Localization | Cytoplasmic | Control | Normal Pituitary |
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| Presentation | ACTH is a purified immunoglobulin fraction of rabbit antiserum that is filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative. |
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| Availability | | Catalog No. | Antibody Type | Dilution | Volume/QTY | | BSB 5015 | Prediluted | Ready-To-Use | 3.0 ml | | BSB 5016 | Prediluted | Ready-To-Use | 7.0 ml | | BSB 5017 | Prediluted | Ready-To-Use | 15.0 ml | | BSB 5018 | Concentrated | 1:250-1:1000 | 0.1 ml | | BSB 5019 | Concentrated | 1:250-1:1000 | 0.5 ml | | BSB 5020 | Concentrated | 1:250-1:1000 | 1.0 ml | | BSB 5021 | Control Slides | | 5 |
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| Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product. |
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