IHC of Calretinin on an FFPE Mesothelioma Tissue
| Intended Use | For In Vitro Diagnostic Use | |||||||||||||||||||||||||||||||||||
| Summary and Explanation | Calretinin is a vitamin D-dependent calcium-binding protein involved in calcium signaling. It is expressed in the central and peripheral nervous system and in many normal and pathological tissues. It stains Mesothelioma and can be used to help differentiate lung tumors. Calretinin is also considered an important diagnostic tool in the differential diagnosis of cystic and solid Ameloblastic Tumors. Anti-calretinin has been shown to be useful in differentiating Mesothelioma from Adenocarcinomas of the lung and other sources. It is also useful in differentiating adrenal-cortical neoplasms from Pheochromocytomas. | |||||||||||||||||||||||||||||||||||
| Antibody Type | Rabbit Monoclonal | Clone | EP1798 * | |||||||||||||||||||||||||||||||||
| Isotype | IgG | Reactivity | Paraffin, Frozen | |||||||||||||||||||||||||||||||||
| Localization | Cytoplasmic, Nuclear | Control | Brain, Testis, Colon, Malignant Mesothelioma, Benign Mesothelial Cells | |||||||||||||||||||||||||||||||||
| Presentation | Calretinin is a rabbit monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative. | |||||||||||||||||||||||||||||||||||
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| Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product. | ||||||||||||||||||||||||||||||||||||
| * The Calretinin antibody, clone EP1798 , has been manufactured using Epitomics RabMab® technology covered under Patent No.’s 5,675,063 and 7,402,409. | ||||||||||||||||||||||||||||||||||||
